The electrochemical-level simulation of neurons brings together many different challenges in the realms of biophysical modelling, numerical analysis, HPC, neuromorphic hardware and software design. To approach these challenges, we recently developed a modular platform, EDEN (https://eden-simulator.org). EDEN offers both a pip installable simulation package for neuroscientists, and a modular construction kit for neuro-simulator programmers to rapidly develop and evaluate new computational methods. It leverages the community standard NeuroML (https://neuroml.org) to integrate with the existing open-source stack of modelling and analysis tools, and minimise the barrier to entry for technical innovations in neural simulation.

Further reading: - the 2022 paper for the high-level design - the 2025 paper for the plug-in architecture